Миланские ученые нашли путь к долголетию с помощью обычных аминокислот
Ученые Миланского университета сделали очень уникальное и важное открытие. Они фактически открыли «коктейль долголетия», который позволяет продлить человеческую жизнь на 12%, а это при нынешней экологии совсем немало. Этот особый коктейль состоит из аминокислот - валина, аминоизокапроновой кислотой и изолейцина.
Возможность увеличивать срок жизни с помощью этого коктейля аминокислот доказано в лабораторных условиях на здоровых мышах среднего возраста мужского пола. Две группы мышей были разбиты по принципу употребления и неупотребления этого коктейля. Результаты были поразительными. Мыши, которые ежедневно принимали вышеуказанные аминокислоты, жили в среднем 869 дней, а группа мышей, не употреблявших аминокислоты, в среднем прожили лишь 774 дня.
Кроме увеличения продолжительности жизни в организме мышей значительно возросла энергетическая подпитка клеток, снизились негативные процессы окисления, приводящие к старению и склонности к онкозаболеваниям, улучшилась мышечная.
от редакции: в связи с тем, что публикация данной "новости" вызвала определенный интерес, отклики и вопросы, мы хотим привести дополнительную информацию, которая ближе подводит нас к первоисточнику - текст новости, датированной октябрем 2010 года на сайте BBC и ссылки на научную публикацию миланских ученых.
http://www.bbc.co.uk/news/health-11482764
Protein cocktail is 'elixir of life
A cocktail of amino acids - the building blocks of proteins - is the latest contender in the age-old search for the elixir of life.
Scientists gave mice drinking water laced with three amino acids. They said the rodents lived significantly longer than other mice fed a normal diet.
The research, reported in a scientific journal, has yet to be tried in people.
The study leader said a large patient trial was needed to provide evidence to convince doctors.
In experiments, middle-aged healthy male mice were given drinking water containing the amino acids leucine, isoleucine and valine.
Dr Enzo Nisoli, of the University of Milan, and colleagues, said it increased the average lifespan of the mice by 12% and boosted their fitness and co-ordination.
They wrote in their paper, published in Cell Metabolism: "Our study offers a rationale for deeply exploring the role of amino acids in prevention and control of age-related disorders in humans."
The amino acids - three of the 20 that make up proteins - have been shown to extend life span in yeast. However, the precise role of these amino acids in humans is unknown.
They are used by bodybuilders to maintain muscle tissue and can be bought in health food stores and online.
http://www.cell.com/cell-metabolism/retrieve/pii/S1550413110003049
Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice
Giuseppe D'Antona1, 2, Maurizio Ragni3, Annalisa Cardile3, Laura Tedesco3, 4, Marta Dossena3, 5, Flavia Bruttini1, 2, Francesca Caliaro1, 2, Giovanni Corsetti6, Roberto Bottinelli1, 2, Michele O. Carruba3, 4, Alessandra Valerio3, 5 and Enzo Nisoli3, 4, 
, 
1 Department of Physiology, Human Physiology Unit, Pavia University, Pavia 27100, Italy
2 Interuniversity Institute of Myology, Pavia University, Pavia 27100, Italy
3 Center for Study and Research on Obesity, Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, Milan University, Milan 20129, Italy
4 Istituto Auxologico Italiano, Milan 20145, Italy
5 Pharmacology Unit, Department of Biomedical Sciences and Biotechnologies, Brescia University, Brescia 25123, Italy
6 Human Anatomy Unit, Department of Biomedical Sciences and Biotechnologies, Brescia University, Brescia 25123, Italy
Summary
Recent evidence points to a strong relationship between increased mitochondrial biogenesis and increased survival in eukaryotes. Branched-chain amino acids (BCAAs) have been shown to extend chronological life span in yeast. However, the role of these amino acids in mitochondrial biogenesis and longevity in mammals is unknown. Here, we show that a BCAA-enriched mixture (BCAAem) increased the average life span of mice. BCAAem supplementation increased mitochondrial biogenesis and sirtuin 1 expression in primary cardiac and skeletal myocytes and in cardiac and skeletal muscle, but not in adipose tissue and liver of middle-aged mice, and this was accompanied by enhanced physical endurance. Moreover, the reactive oxygen species (ROS) defense system genes were upregulated, and ROS production was reduced by BCAAem supplementation. All of the BCAAem-mediated effects were strongly attenuated in endothelial nitric oxide synthase null mutant mice. These data reveal an important antiaging role of BCAAs mediated by mitochondrial biogenesis in mammals.
Graphical Abstract
Highlights
► BCAAem supplementation increases the average life span of male mice ► BCAAem activates mTOR and eNOS signaling pathways ► BCAAem increases mitochondrial biogenesis and ROS defense system in middle-aged mice ► BCAAem supplementation improves age-related muscle deficits
Article Outline
- Results
- Average Life Span Is Extended by BCAAem Supplementation in Mice
- Hormonal Profile in BCAAem-Supplemented Mice
- Mitochondrial Biogenesis Is Increased by BCAAem in a Tissue-Specific Manner
- BCAAem Preserves Muscle Morphology and Improves Functional Capacity
- BCAAem Decreases Mitochondrial Oxidative Stress in Cardiac and Skeletal Muscles
- eNOS Is Involved in BCAAem Effects on Mitochondrial Biogenesis and ROS Defense System
- mTOR Signaling Is Involved in BCAAem Effects on Mitochondrial Biogenesis
- Experimental Procedures
- Animals, Diets, and Treatments
- Study Design for Survival Analysis
- Analytical Procedures
- HL-1 Cell Cultures and Treatments
- Cardiomyocyte and Myocyte Preparation and Treatment
- Gene Expression and Mitochondrial Biogenesis Methods
- Mitochondrial Oxidative Stress
- Training, Exercise Tolerance, and Motor Coordination Tests
- Muscle Fiber Size
- Statistical Analysis